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Strong animal evidence, limited human surgical trials

collection::bone-joint-health

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Both circulating GH and IGF increase in response to exercise (211, 212) and although the IGF-1 response to exercise is not as pronounced as the GH one, it is not necessarily a consequence of GH release (213, 214) as it was shown by the fact that IGF-1 can rise in response to exercise in patients with pituitary insufficiency (212)